Article

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

2019-05-09

Abstract excerpt

<h4>Summary</h4> Oncogenic transformation alters the metabolism of cellular nutrients to sustain tumor growth. We here define a mechanism by which modifications in cholesterol metabolism control the formation of pancreatic ductal adenocarcinoma (PDAC). Disruption of distal cholesterol biosynthesis by means of conditional inactivation of Nsdhl in mice bearing a tumor-inducing Kras mutation ( Kras G12D ) preven...

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Literature Corpus work: c0a7b62a-727e-52ce-a7f4-c215fdfab002
DOI: 10.1101/633719

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