Article
In vivo reprogramming drives Kras-induced cancer development.
Nature communications - 25 May 2018
Shibata Hirofumi, Komura Shingo, Yamada Yosuke, Sankoda Nao, Tanaka Akito, Ukai Tomoyo, Kabata Mio, Sakurai Satoko, Kuze Bunya, Woltjen Knut, Haga Hironori, Ito Yatsuji, Kawaguchi Yoshiya, Yamamoto Takuya, Yamada Yasuhiro
Abstract excerpt
The faithful shutdown of the somatic program occurs in the early stage of reprogramming. Here, we examined the effect of in vivo reprogramming on Kras-induced cancer development. We show that the transient expression of reprogramming factors (1-3 days) in pancreatic acinar cells results in the transient repression of acinar cell enhancers, which are similarly observed in pancreatitis. We next demonstrate that...
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