Article

Ductal pancreatic cancer interception by FGFR2 abrogation

2024-10-18

Abstract excerpt

<h4>ABSTRACT</h4> Activating KRAS mutations are a key feature of pancreatic ductal adenocarcinoma (PDA) and drive tumor initiation and progression. However, mutant KRAS by itself is weakly oncogenic. The pathways that cooperate with mutant KRAS to induce tumorigenesis are less-defined. Analyzing organoids and murine and human pancreatic specimens, we found that the receptor tyrosine kinase FGFR2 was progressively...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 382cc711-6bcd-58f4-827b-f206175c01a0
DOI: 10.1101/2024.10.16.618726

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ductal pancreatic cancer interception by FGFR2 abrogationDOI 10.1101/2024.10.16.618726Read

FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development.Semantic proximity Read

Kras as a key oncogene and therapeutic target in pancreatic cancerSemantic proximity Read

Mutant KRAS in the initiation of pancreatic cancer.Semantic proximity Read

The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.Semantic proximity Read

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer.Semantic proximity Read

An Essential Role for <i>Argonaute 2</i> in EGFR-KRAS Signaling in Pancreatic Cancer DevelopmentSemantic proximity Read

Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.Semantic proximity Read

KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition.Semantic proximity Read

Cancer interception with KRAS inhibitors in preclinical models of pancreatic ductal adenocarcinoma.Semantic proximity Read

Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesisSemantic proximity Read

Loss of FGFR4 promotes the malignant phenotype of PDAC.Semantic proximity Read

Deciphering role of FGFR signalling pathway in pancreatic cancerSemantic proximity Read