Article

Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent

2025-03-03

Abstract excerpt

A constitutively active mutant of the receptor protein-tyrosine kinase KIT is a major cause of gastrointestinal stromal tumours (GISTs). Recently, we discovered that during biosynthetic transport, the KIT mutant (KIT mut ) is retained in the Golgi/ trans- Golgi network (TGN), where it activates downstream molecules. This retention is dependent on the phospholipase Cγ2–protein kinase D2–PI4 kinase IIIβ (PLCγ2–PKD...

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Literature Corpus work: b43b8fba-4a7f-5836-8c0d-2481e2b01a68
DOI: 10.1101/2025.03.02.640696

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