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Article

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications - 17 Sept 2020

Naka Kazuhito, Ochiai Ryosuke, Matsubara Eriko, Kondo Chie, Yang Kyung-Min, Hoshii Takayuki, Araki Masatake, Araki Kimi, Sotomaru Yusuke, Sasaki Ko, Mitani Kinuko, Kim Dong-Wook, Ooshima Akira, Kim Seong-Jin

Abstract excerpt

Although advanced lipidomics technology facilitates quantitation of intracellular lipid components, little is known about the regulation of lipid metabolism in cancer cells. Here, we show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity in murine chronic myelogenous leukaemia (CML) stem cells in vivo. Sophisticated lipidomics analyses revealed...

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Source

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Identifiers

PMID: 32943626
DOI: 10.1038/s41467-020-18491-9
PMCID: PMC7499193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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