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Article

Lipid rafts are required for Kit survival and proliferation signals.

Blood - 15 Sept 2007

Jahn Thomas, Leifheit Erica, Gooch Stacie, Sindhu Simran, Weinberg Kenneth

Abstract excerpt

In addition to its physiologic role as central regulator of the hematopoietic and reproductive systems, the Kit receptor tyrosine kinase (RTK) is pathologically overexpressed in some forms of leukemia and constitutively activated by oncogenic mutations in mast-cell proliferations and gastrointestinal stromal tumors. To gain insight into the general activation and signaling mechanisms of RTKs, we investigated the...

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Source

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Identifiers

PMID: 17554062
DOI: 10.1182/blood-2006-05-020925
PMCID: PMC1976347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lipid rafts are required for Kit survival and proliferation signals.PMID 17554062Read ↗

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