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Article

Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours.

Cancer letters - 28 Feb 2018

Obata Yuuki, Horikawa Keita, Shiina Isamu, Takahashi Tsuyoshi, Murata Takatsugu, Tasaki Yasutaka, Suzuki Kyohei, Yonekura Keita, Esumi Hiroyasu, Nishida Toshirou, Abe Ryo

Abstract excerpt

Most gastrointestinal stromal tumours (GISTs) are caused by constitutively active mutations in Kit tyrosine kinase. The drug imatinib, a specific Kit inhibitor, improves the prognosis of metastatic GIST patients, but these patients become resistant to the drug by acquiring secondary mutations in the Kit kinase domain. We recently reported that a Kit mutant causes oncogenic signals only on the Golgi apparatus in...

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Identifiers

PMID: 29196126
DOI: 10.1016/j.canlet.2017.11.032

Genes

COPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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