Article
Colocalization of phospholipase D1 and GTP-binding-defective mutant of ADP-ribosylation factor 6 to endosomes and lysosomes.
FEBS letters - 15 Jan 1999
Toda K, Nogami M, Murakami K, Kanaho Y, Nakayama K
Abstract excerpt
Phospholipase D (PLD) is involved in various aspects of cellular function. Two isoforms, PLD1 and PLD2, have been identified. PLD1, which has two splicing variants, is regulated by various factors, including ADP-ribosylation factor (ARF). We here show that both variants of PLD1 are predominantly...
Topics
- ADP-Ribosylation Factor 6
- ADP-Ribosylation Factors
- Animals
- Brefeldin A
- Cell Line
- Chlorocebus aethiops
- Endoplasmic Reticulum
- Endosomes
- Fluorescent Antibody Technique
- GTP-Binding Proteins
- Golgi Apparatus
- Guanosine Triphosphate
- Humans
- Isoenzymes
- Liver
- Lysosomes
- Mice
- Mutation