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Article

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.

Science (New York, N.Y.) - 6 Sept 2002

Doray Balraj, Ghosh Pradipta, Griffith Janice, Geuze Hans J, Kornfeld Stuart

Abstract excerpt

The Golgi-localized, gamma-ear-containing, adenosine diphosphate ribosylation factor-binding proteins (GGAs) are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) in the Golgi and have an essential role in lysosomal enzyme sorting. Here the GGAs and the coat protein adaptor protein-1 (AP-1) were shown to colocalize in clathrin-coated buds of the trans-Golgi networks of mouse L cells and human...

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Source

Identifiers

PMID: 12215646
DOI: 10.1126/science.1075327

Genes

GGA1
GGA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.PMID 12215646Read ↗

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.Semantic proximity Read ↗

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.Semantic proximity Read ↗

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.Semantic proximity Read ↗

GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.Semantic proximity Read ↗

Multiple phosphorylation events regulate the subcellular localization of GGA1.Semantic proximity Read ↗

Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.Semantic proximity Read ↗

Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.Semantic proximity Read ↗

Sorting of mannose 6-phosphate receptors mediated by the GGAs.Semantic proximity Read ↗

Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.Semantic proximity Read ↗

Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network.Semantic proximity Read ↗

GARP Complex in Golgi Physiology.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

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