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Article

Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity.

Oncotarget - 3 Nov 2015

Farina Antonietta Rosella, Cappabianca Lucia, Ruggeri Pierdomenico, Gneo Luciana, Maccarone Rita, Mackay Andrew Reay

Abstract excerpt

In human SH-SY5Y neuroblastoma (NB) cells, nascent immature N-glycosylated 110kDa TrkA moves rapidly from the endoplasmic reticulum (ER) to the Golgi Network (GN), where it matures into the 140kDa receptor prior to being transported to the cell surface, creating GN and cell surface pools of inactive receptor maintained below the spontaneous activation threshold by a full compliment of inhibitory domains and...

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Identifiers

PMID: 26415233
DOI: 10.18632/oncotarget.5802
PMCID: PMC4742131

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