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Article

Sustained Mutant KIT Activation in the Golgi Complex Is Mediated by PKC-θ in Gastrointestinal Stromal Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2017

Kim Won Kyu, Yun SeongJu, Park Cheol Keun, Bauer Sebastian, Kim Jiyoon, Lee Min Goo, Kim Hoguen

Abstract excerpt

PURPOSE: Tumorigenesis of gastrointestinal stromal tumors (GIST) is driven by gain-of-function mutations in the KIT gene, which result in overexpression of activated mutant KIT proteins (MT-KIT). However, the mechanism of MT-KIT overexpression is poorly understood. EXPERIMENTAL DESIGN: By protein expression analysis and immunofluorescent microscopic analysis, we determine the stability and localization of MT-KIT...

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Source

Identifiers

PMID: 27440273
DOI: 10.1158/1078-0432.CCR-16-0521

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sustained Mutant KIT Activation in the Golgi Complex Is Mediated by PKC-θ in Gastrointestinal Stromal Tumors.PMID 27440273Read ↗

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