Article

Interpreting mammalian evolutionary constraint at synonymous sites in light of the unwanted transcript hypothesis

2024-04-26

Abstract excerpt

The unwanted transcript hypothesis presents a potential explanation for cryptic evolutionary constraint at synonymous sites in species with low effective population sizes, such as humans and other mammals. Selection for higher GC content and against mutations that alter splicing in native transcripts is predicted to shape synonymous site content and protect against unwanted transcripts. Here, we interpret mammalia...

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Literature Corpus work: b4175ddb-25a8-5d85-baec-61078f9f4f25
DOI: 10.1101/2024.04.23.590689

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