Article

The landscape of gene loss and missense variation across the mammalian tree informs on gene essentiality

2024-05-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The degree of gene and sequence preservation across species provides valuable insights into the relative necessity of genes from the perspective of natural selection. Here, we developed novel interspecies metrics across 462 mammalian species, GISMO (Gene identity score of mammalian orthologs) and GISMO-mis (GISMO-missense), to quantify gene loss traversing millions of years...

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Literature Corpus work: f04ad3ca-4206-577c-88ac-7fc5924cfa06
DOI: 10.1101/2024.05.16.594531

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