Article

Evolutionary constraint and innovation across hundreds of placental mammals

2023-03-09

Abstract excerpt

Evolutionary constraint and acceleration are powerful, cell-type agnostic measures of functional importance. Previous studies in mammals were limited by species number and reliance on human-referenced alignments. We explore the evolution of placental mammals, including humans, through reference-free whole-genome alignment of 240 species and protein-coding alignments for 428 species. We estimate 10.7% of the human...

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Literature Corpus work: ceb35d15-f33e-5856-9f52-da1ba58670d8
DOI: 10.1101/2023.03.09.531574

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