Article
Hearing silence: non-neutral evolution at synonymous sites in mammals.
Nature reviews. Genetics - 1 Feb 2006
Chamary J V, Parmley Joanna L, Hurst Laurence D
Abstract excerpt
Although the assumption of the neutral theory of molecular evolution - that some classes of mutation have too small an effect on fitness to be affected by natural selection - seems intuitively reasonable, over the past few decades the theory has been in retreat. At least in species with large populations, even synonymous mutations in exons are not neutral. By contrast, in mammals, neutrality of these mutations is...
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