Article
Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.
Molecular biology and evolution - 1 Jan 2010
Eory Lél, Halligan Daniel L, Keightley Peter D
Abstract excerpt
Protein-coding sequences make up only about 1% of the mammalian genome. Much of the remaining 99% has been long assumed to be junk DNA, with little or no functional significance. Here, we show that in hominids, a group with historically low effective population sizes, all classes of noncoding DNA evolve more slowly than ancestral transposable elements and so appear to be subject to significant evolutionary...
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