Article
Differential GC content between exons and introns establishes distinct strategies of splice-site recognition.
Cell reports - 31 May 2012
Amit Maayan, Donyo Maya, Hollander Dror, Goren Amir, Kim Eddo, Gelfman Sahar, Lev-Maor Galit, Burstein David, Schwartz Schraga, Postolsky Benny, Pupko Tal, Ast Gil
Abstract excerpt
During evolution segments of homeothermic genomes underwent a GC content increase. Our analyses reveal that two exon-intron architectures have evolved from an ancestral state of low GC content exons flanked by short introns with a lower GC content. One group underwent a GC content elevation that abolished the differential exon-intron GC content, with introns remaining short. The other group retained the overall...
Topics
- Base Composition
- DNA
- DNA, Recombinant
- Evolution, Molecular
- Exons
- Humans
- Introns
- Models, Genetic
- Mutation
- RNA Splice Sites
- RNA Splicing
- Spliceosomes