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Article

Transposable element-driven transcript diversification and its relevance to genetic disorders.

Gene - 10 Mar 2015

Ayarpadikannan Selvam, Lee Hee-Eun, Han Kyudong, Kim Heui-Soo

Abstract excerpt

The human genome project and subsequent gene annotation projects have shown that the human genome contains 22,000-25,000 functional genes. Therefore, it is believed that the diversity of protein repertoire is achieved by the alternative splicing (AS) mechanism. Transposable elements (TEs) are mobile in nature and can therefore alter their position in the genome. The insertion of TEs into a new gene region can...

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PMID: 25617522
DOI: 10.1016/j.gene.2015.01.039

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