Article

A-to-I RNA editing uncovers hidden signals of adaptive genome evolution in animals

2017-12-04

Abstract excerpt

In animals, the most common type of RNA editing is the deamination of adenosines (A) into inosines (I). Because inosines base-pair with cytosines (C), they are interpreted as guanosines (G) by the cellular machinery and genomically encoded G alleles at edited sites mimic the function of edited RNAs. The contribution of this hardwiring effect on genome evolution remains obscure. We looked for population genomics si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 797dadae-f5e5-5d8c-9849-4f469accd506
DOI: 10.1101/228734

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A-to-I RNA editing uncovers hidden signals of adaptive genome evolution in animalsDOI 10.1101/228734Read

An Evolutionary Landscape of A-to-I RNA Editome across Metazoan SpeciesSemantic proximity Read

Nonsynonymous A-to-I RNA editing contributes to burden of deleterious missense variants in healthy individualsSemantic proximity Read

Fascination with RNA Editing: In the Lights of Evolution and Biology.Semantic proximity Read

Human A-to-I RNA editing SNP loci are enriched in GWAS signals for autoimmune diseases and under balancing selection.Semantic proximity Read

The implications of APOBEC3-mediated C-to-U RNA editing for human disease.Semantic proximity Read

Screening of human SNP database identifies recoding sites of A-to-I RNA editing.Semantic proximity Read

Population and allelic variation of A-to-I RNA editing in human transcriptomes.Semantic proximity Read

The dynamic epitranscriptome: A to I editing modulates genetic informationSemantic proximity Read

RESIC: A tool for comprehensive adenosine to inosine RNA Editing Site Identification and ClassificationSemantic proximity Read

Deciphering the functions and regulation of brain-enriched A-to-I RNA editing.Semantic proximity Read

RNA editing: a driving force for adaptive evolution?Semantic proximity Read

ADARs: allies or enemies? The importance of A‐to‐I RNA editing in human disease: from cancer to HIV‐1Semantic proximity Read