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Article

Genomic selective constraints in murid noncoding DNA.

PLoS genetics - 24 Nov 2006

Gaffney Daniel J, Keightley Peter D

Abstract excerpt

Recent work has suggested that there are many more selectively constrained, functional noncoding than coding sites in mammalian genomes. However, little is known about how selective constraint varies amongst different classes of noncoding DNA. We estimated the magnitude of selective constraint on a large dataset of mouse-rat gene orthologs and their surrounding noncoding DNA. Our analysis indicates that there are...

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PMID: 17166057
DOI: 10.1371/journal.pgen.0020204
PMCID: PMC1657059

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Source receipt: pubmed, retrieved 7 Sept 2026.

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