Article

Tau depletion in human neurons mitigates Aβ-driven toxicity

2022-12-23

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist of amyloid-β (Aβ) and hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out of the microtubule-associa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b000945-ef9f-5066-802f-5534be379a52
DOI: 10.1101/2022.12.23.521772

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tau depletion in human neurons mitigates Aβ-driven toxicityDOI 10.1101/2022.12.23.521772Read

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau PathologySemantic proximity Read

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H MutationSemantic proximity Read

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCsSemantic proximity Read

Cultivation, differentiation, and lentiviral transduction of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons for studying human TAUSemantic proximity Read

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer’s disease iPSC-derived cortical organoidsSemantic proximity Read

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.Semantic proximity Read

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neuronsSemantic proximity Read

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?Semantic proximity Read

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.Semantic proximity Read

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerabilitySemantic proximity Read