Article

A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection

2022-05-16

Abstract excerpt

Ancestral SARS-CoV-2 lacks the intrinsic ability to bind to the mouse ACE2 receptor and therefore establishment of SARS-CoV-2 mouse models has been limited to the use of mouse-adapted viruses or genetically modified mice. Interestingly, some of the variants of concern, such as the beta B.1.351 variant, show an improved binding to the mouse receptor and hence better replication in different Wild type (WT) mice spec...

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Literature Corpus work: b3da9fd0-0eaa-579d-ab19-63a01541145b
DOI: 10.1101/2022.05.13.491916

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