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Article

Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant

11 Nov 2021

Abstract excerpt

Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. However, the development of mouse-adapted virus strains has revealed key mutations in the SARS-CoV-2 spike protein that increase infectivity, and interestingly, many of these mutations are also present in...

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PMID: 34835069
DOI: 10.3390/v13112263

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