Article

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

2021-05-04

Abstract excerpt

The emergence of SARS-CoV-2 has resulted in a worldwide pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of COVID-19 disease have been hampered by the lack of robust mouse models. To overcome this barrier, we utilized a reverse genetic system to generate a mouse-adapted strain of SARS-CoV-2. Incorporating key mutations found in SARSCoV-2 variants, this mode...

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Literature Corpus work: 36e26c9b-4e21-5967-b106-78f2dc5854bc
DOI: 10.1101/2021.05.03.442357

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