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Comparative characterization of SARS‐CoV‐2 variants of concern and mouse‐adapted strains in mice

23 Mar 2022

Abstract excerpt

SARS-CoV-2 has evolved into a panel of variants of concern (VOCs) and constituted a sustained threat to global health. The wildtype (WT) SARS-CoV-2 isolates fail to infect mice, while the Beta variant, one of the VOCs, has acquired the capability to infect standard laboratory mice, raising a spreading risk of SARS-CoV-2 from humans to mice. However, the infectivity and pathogenicity of other VOCs in mice remain...

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PMID: 35322439
DOI: 10.1002/jmv.27735

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