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Toll-Like Receptor Agonist R848 Protects Mice from Lethal SARS-CoV-2 Infections

2021-02-10

Abstract excerpt

Background: An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2) pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection and recapitulate lung disease like those seen in humans. The angiotensin-converting enzyme 2 (ACE2) is a functional receptor for SARS-CoV-2, but mice are resistant to the infection because their ACE2 is incompatible with the receptor-binding domain (RBD)...

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Literature Corpus work
56e260f2-9a34-59a5-a074-c1a14cc44209
DOI
10.2139/ssrn.3783087
Open publication

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