Article
A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures
2020-05-07
Abstract excerpt
Coronaviruses are prone to emergence into new host species most recently evidenced by SARS-CoV-2, the causative agent of the COVID-19 pandemic. Small animal models that recapitulate SARS-CoV-2 disease are desperately needed to rapidly evaluate medical countermeasures (MCMs). SARS-CoV-2 cannot infect wildtype laboratory mice due to inefficient interactions between the viral spike (S) protein and the murine ortholog...
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Identifiers and source
- Literature Corpus work
- 0946baf4-5bfb-5dcb-a71d-46d086c9b927
- DOI
- 10.1101/2020.05.06.081497