Article

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

2020-11-11

Abstract excerpt

The ongoing SARS-CoV-2 pandemic has brought an urgent need for animal models to study the pathogenicity of the virus. Herein, we generated and characterized a novel mouse-adapted SARS-CoV-2 strain, named MASCp36, that causes severe acute respiratory symptoms and mortality in standard laboratory mice. Particularly, this model exhibits age and gender related skewed distribution of mortality akin to severe COVID-19,...

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Literature Corpus work: a37f9a1d-85ac-5871-a17e-8acdf9e7aea0
DOI: 10.1101/2020.11.10.377333

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