Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route

14 Dec 2021

Abstract excerpt

COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2, which also can cross-transmit to many animals but not mice. Genetic modifications of SARS-CoV-2 or mice enable the mice susceptible to viral infection. Although neither is the natural situation, they are currently utilized to establish mouse infection models. Here we report a direct contact transmission of SARS-CoV-2 variant B.1.351 in wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Long-Term Effects of COVID-19
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34907154
DOI: 10.1038/s41392-021-00848-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission routePMID 34907154Read ↗

SARS-CoV-2 B.1.351 (beta) variant shows enhanced infectivity in K18-hACE2 transgenic mice and expanded tropism to wildtype mice compared to B.1 variantSemantic proximity Read ↗

B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strainsSemantic proximity Read ↗

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing miceSemantic proximity Read ↗

Emerging SARS-CoV-2 variants expand species tropism to murinesSemantic proximity Read ↗

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19Semantic proximity Read ↗

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype MiceSemantic proximity Read ↗

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.Semantic proximity Read ↗

Toll-Like Receptor Agonist R848 Protects Mice from Lethal SARS-CoV-2 InfectionsSemantic proximity Read ↗

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J miceSemantic proximity Read ↗

Host immune responses associated with SARS-CoV-2 Omicron infection result in protection or pathology during reinfection depending on mouse genetic background.Semantic proximity Read ↗

Comparative characterization of SARS‐CoV‐2 variants of concern and mouse‐adapted strains in miceSemantic proximity Read ↗

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challengeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.