Article

Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations

2021-11-11

Abstract excerpt

<h4>Background: </h4> Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role of MED12m is still unclear in the pathogenesis of UFs. Therefore, we investigated the differences in DNA methylome, transcriptome, and histological features between MED12m-positive and -negative UFs. <h4>Methods:</h4> DNA methylomes and transcriptomes were o...

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Literature Corpus work: b3da2c73-cc2d-5282-a730-32279312d3d4
DOI: 10.21203/rs.3.rs-1041773/v1

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