Article
Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids.
Cell reports - 17 Dec 2019
George Jitu Wilson, Fan Huihui, Johnson Benjamin, Carpenter Tyler James, Foy Kelly Katherine, Chatterjee Anindita, Patterson Amanda Lynn, Koeman Julie, Adams Marie, Madaj Zachary Brian, Chesla David, Marsh Erica Elizabeth, Triche Timothy Junius, Shen Hui, Teixeira Jose Manuel
Abstract excerpt
Uterine fibroids are benign myometrial smooth muscle tumors of unknown etiology that, when symptomatic, are the most common indication for hysterectomy in the United States. Unsupervised clustering of results from DNA methylation analyses segregates normal myometrium from fibroids and further segregates the fibroids into subtypes characterized by MED12 mutation or activation of either HMGA2 or HMGA1 expression....
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