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Article

Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations.

Scientific reports - 26 May 2022

Maekawa Ryo, Sato Shun, Tamehisa Tetsuro, Sakai Takahiro, Kajimura Takuya, Sueoka Kotaro, Sugino Norihiro

Abstract excerpt

Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role of MED12m is still unclear in the pathogenesis of UFs. Therefore, we investigated the differences in DNA methylome, transcriptome, and histological features between MED12m-positive and -negative UFs. DNA methylomes and transcriptomes were obtained from MED12m-positive and...

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Identifiers

PMID: 35618793
DOI: 10.1038/s41598-022-12899-7
PMCID: PMC9135739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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