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Article

RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids.

Journal of molecular endocrinology - 1 Nov 2023

Ishikawa Hiroshi, Kobayashi Tatsuya, Kaneko Meika, Saito Yoshiko, Shozu Makio, Koga Kaori

Abstract excerpt

Abstract: Uterine fibroids (UFs) are benign tumors arising from the uterus, characterized by accumulation of abundant extracellular matrix (ECM) and sex steroid-dependent growth. Women with symptomatic UFs have reduced quality of life and decreased labor productivity. Among the driver gene mutations identified in UFs, mutations in MED12, a component of the cyclin-dependent kinase (CDK) Mediator module, are the...

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Identifiers

PMID: 37668348
DOI: 10.1530/JME-23-0039

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids.PMID 37668348Read ↗

Uterine Fibroids: Bridging Genomic Defects and Chronic InflammationSemantic proximity Read ↗

The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.Semantic proximity Read ↗

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroidsSemantic proximity Read ↗

Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas.Semantic proximity Read ↗

UTERINE FIBROIDS.Semantic proximity Read ↗

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroidsSemantic proximity Read ↗

Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutationsSemantic proximity Read ↗

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Semantic proximity Read ↗

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.Semantic proximity Read ↗

Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogrammingSemantic proximity Read ↗

Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations.Semantic proximity Read ↗

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.Semantic proximity Read ↗

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