Article

Integrated epigenome, exome and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids

2018-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Uterine fibroids are benign myometrial smooth muscle tumors of unknown etiology that when symptomatic are the most common indication for hysterectomy in the USA. We conducted an integrated analysis of fibroids and adjacent normal myometria by whole exome sequencing, Infinium MethylationEPIC array, and RNA-sequencing. Unsupervised clustering by DNA methylation segregated normal myometria from fib...

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Literature Corpus work: 295c25d3-632f-56da-9fa2-f0ec53ec8105
DOI: 10.1101/452342

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