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Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

2020-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Although neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19 vaccines and have received emergency use authorization as therapeutics, viral escape mutants could compromise their efficacy. To define the immune-selected mutational landscape in S protein, we used a VSV-eGFP-SARS-CoV-2-S chimeric virus and 19 neutralizing monoclonal antibodies (mAbs) against the re...

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Literature Corpus work
b3bfec6f-2eee-56bb-aa48-4f7f91dd03cc
DOI
10.1101/2020.11.06.372037
Open publication

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Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralizationDOI 10.1101/2020.11.06.372037
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