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Article

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

2020-09-10

Abstract excerpt

Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and make a major contribution to the neutralizing antibody response elicited by infection. Here, we describe a deep mutational scanning method to map how all amino-acid mutations in the RBD affect antibody binding, and apply this method to 10 human monoclonal antibodies. The escape mutations cluster on sever...

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Identifiers and source

Literature Corpus work
d4b42e05-8965-5da7-bbf7-8c58f18ff44a
DOI
10.1101/2020.09.10.292078
Open publication

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Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognitionDOI 10.1101/2020.09.10.292078
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