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Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.

Cell host & microbe - 10 Mar 2021

Liu Zhuoming, VanBlargan Laura A, Bloyet Louis-Marie, Rothlauf Paul W, Chen Rita E, Stumpf Spencer, Zhao Haiyan, Errico John M, Theel Elitza S, Liebeskind Mariel J, Alford Brynn, Buchser William J, Ellebedy Ali H, Fremont Daved H, Diamond Michael S, Whelan Sean P J

Abstract excerpt

Neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19 vaccines and have received emergency use authorization as therapeutics. However, viral escape mutants could compromise efficacy. To define immune-selected mutations in the S protein, we exposed a VSV-eGFP-SARS-CoV-2-S chimeric virus, in which the VSV glycoprotein is replaced with the S protein, to 19 neutralizing monoclonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33535027
DOI: 10.1016/j.chom.2021.01.014
PMCID: PMC7839837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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