Article

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

2020-11-05

Abstract excerpt

SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is the most divergent region of S, and provide epidemiological, clinical, and molecular characterization of a prevalent RBM variant, N439K. We demonstrate that N439K S protein has enhanced binding...

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Literature Corpus work: a63579da-8a79-5974-846b-5fbfa9dae827
DOI: 10.1101/2020.11.04.355842

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