Article

A cocktail of SARS-CoV-2 spike stem helix domain and receptor binding domain human monoclonal antibodies prevent the emerge of viral escape mutants

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Neutralizing antibodies (NAbs) targeting the spike (S) glycoprotein remain a crucial therapeutic strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, emerging viral variants have escaped all Food and Drug Administration (FDA)-approved NAb treatments, underscoring the urgent need for effective therapeutic alternatives. Using a nanoluciferase (Nluc)-expressing at...

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Literature Corpus work: e47d27d9-3065-5aac-a193-ab4c35ad0948
DOI: 10.1101/2025.10.16.682699

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