Article
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
Cell - 4 Mar 2021
Thomson Emma C, Rosen Laura E, Shepherd James G, Spreafico Roberto, da Silva Filipe Ana, Wojcechowskyj Jason A, Davis Chris, Piccoli Luca, Pascall David J, Dillen Josh, Lytras Spyros, Czudnochowski Nadine, Shah Rajiv, Meury Marcel, Jesudason Natasha, De Marco Anna, Li Kathy, Bassi Jessica, O'Toole Aine, Pinto Dora, Colquhoun Rachel M, Culap Katja, Jackson Ben, Zatta Fabrizia, Rambaut Andrew, Jaconi Stefano, Sreenu Vattipally B, Nix Jay, Zhang Ivy, Jarrett Ruth F, Glass William G, Beltramello Martina, Nomikou Kyriaki, Pizzuto Matteo, Tong Lily, Cameroni Elisabetta, Croll Tristan I, Johnson Natasha, Di Iulio Julia, Wickenhagen Arthur, Ceschi Alessandro, Harbison Aoife M, Mair Daniel, Ferrari Paolo, Smollett Katherine, Sallusto Federica, Carmichael Stephen, Garzoni Christian, Nichols Jenna, Galli Massimo, Hughes Joseph, Riva Agostino, Ho Antonia, Schiuma Marco, Semple Malcolm G, Openshaw Peter J M, Fadda Elisa, Baillie J Kenneth, Chodera John D, Rihn Suzannah J, Lycett Samantha J, Virgin Herbert W, Telenti Amalio, Corti Davide, Robertson David L, Snell Gyorgy
Abstract excerpt
SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecular characterization of a prevalent, sentinel RBM mutation, N439K. We demonstrate N439K S protein has enhanced binding...
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