Structural Insights into the SARS-CoV-2 Spike Protein and Its Implications for Antibody Resistance.

Abstract excerpt

The COVID-19 pandemic, caused by SARS-CoV-2, has profoundly affected global health and the economy. The emergence of variants with spike mutations, particularly within the receptor-binding domain (RBD), has reduced the efficacy of many neutralizing antibodies (nAbs), and recent variants, including KP.3 and other circulating strains, show partial escape from infection- or vaccine-induced immunity. To overcome...

Topics

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• Antibodies, Neutralizing
• Antibodies, Viral
• COVID-19
• Mutation
• SARS-CoV-2
• Spike Glycoprotein, Coronavirus