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Article

Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects.

Journal of virology - 12 Jan 2022

Lusvarghi Sabrina, Wang Wei, Herrup Rachel, Neerukonda Sabari Nath, Vassell Russell, Bentley Lisa, Eakin Ann E, Erlandson Karl J, Weiss Carol D

Abstract excerpt

Mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants can compromise the effectiveness of therapeutic antibodies. Most clinical-stage therapeutic antibodies target the spike receptor binding domain (RBD), but variants often have multiple mutations in several spike regions. To help predict antibody potency against emerging variants, we evaluated 25 clinical-stage...

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Share to Amino Acid Substitution
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 34668774
DOI: 10.1128/JVI.01110-21
PMCID: PMC8754225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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