Article

Histone Lactylation Drives CD8 T Cell Metabolism and Function

2023-08-27

Abstract excerpt

<h4>Summary</h4> The activation and functional differentiation of CD8 T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification (hPTM); however, the relevance of histone lactylation in the context of CD8 T cell activation and function is not known. Here, we show the enrichment of H3K18-lactylation (H3K18la) and H3K9-...

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Literature Corpus work: b3aae9a3-a146-5181-8858-38b8b90f5083
DOI: 10.1101/2023.08.25.554830

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