Article
Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell Lines
2026-01-12
Abstract excerpt
Tumor-derived lactate is increasingly recognized as an immunosuppressive metabolite within the tumor microenvironment (TME), with emerging evidence highlighting its role beyond metabolism to include epigenetic and immune regulatory functions. While prior studies have primarily focused on individual immune checkpoints, most prominently PD-L1, it remains unclear whether lactate broadly coordinates the expression of...
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Identifiers and source
- Literature Corpus work
- 4221abe4-eeb3-51dd-9f22-e894f82268a5
- DOI
- 10.64898/2026.01.11.698903