Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma

Abstract excerpt

Hemangiosarcoma (HSA) is a malignant endothelial tumor that occurs frequently in dogs but is rare in other species including humans. Due to its aggressive behavior and limited therapeutic options, patient prognosis is generally poor. Tumor cells produce excess lactate via anerobic glycolysis, and it regulate gene expressions through histone lactylation in response to cellular metabolic conditions. However, how his...

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• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Epigenetics and DNA Methylation
• Ferroptosis and cancer prognosis
• Gestational Diabetes Research and Management
• Liver Disease Diagnosis and Treatment
• Pancreatic function and diabetes
• Renal cell carcinoma treatment

Identifiers and source

Literature Corpus work

19acea4c-c3c2-5f7b-84ea-f35a6b182749

DOI

10.1101/2025.08.12.669864