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H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response

30 Aug 2024

Abstract excerpt

T cell killing activity and enhances immunotherapy efficacy. Clinically, H3K9la positively correlates with IL-11 expression and unfavorable immunotherapy responses in patients. This study reveals the crucial role of histone lactylation in immune escape, providing insights into immunotherapy strategies for HNSCC.

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Identifiers

PMID: 39216002
DOI: 10.1016/j.celrep.2024.114686

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