Article

Histone lactylation: a new epigenetic mark in the malaria parasite <i>Plasmodium</i>

2024-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum . Here, we characterised a new epigenetic mark, histone lactylation, recently discovered in humans: it was found in two human malaria parasites, P. falciparum and P. knowlesi , and also in vivo in two rodent malaria models. Histones were lactylated rapidly in response to elevated lactate le...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a696e709-befc-514f-a98b-3836eea0c99b
DOI: 10.1101/2024.08.19.608576

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Histone lactylation: a new epigenetic mark in the malaria parasite <i>Plasmodium</i>DOI 10.1101/2024.08.19.608576Read

Histone lactylation: A new epigenetic axis for host-parasite signalling in malaria?Semantic proximity Read

Lactylated histones mark virulence gene families in the malaria parasite <i>Plasmodium falciparum</i>Semantic proximity Read

Multiple dimensions of epigenetic gene regulation in the malaria parasite <i>Plasmodium falciparum</i>Semantic proximity Read

Histone Lactylation Drives CD8 T Cell Metabolism and FunctionSemantic proximity Read

Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite <i>Toxoplasma gondii</i>Semantic proximity Read

Epigenetic Regulation and Chromatin Remodeling in Malaria ParasitesSemantic proximity Read

Disease Tolerance Acquired Through Repeated <i>Plasmodium</i> Infection Involves Epigenetic Reprogramming of Innate Immune CellsSemantic proximity Read

Epigenetic regulation underlying <i>Plasmodium berghei</i> gene expression during its developmental transition from host to vectorSemantic proximity Read

Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria ParasitesSemantic proximity Read

Transcriptome and histone epigenome of <i>Plasmodium vivax</i> salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiationSemantic proximity Read

A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasiteSemantic proximity Read

H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3.Semantic proximity Read