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Lactylproteome analysis indicates histone H4K12 lactylation as a novel biomarker in triple-negative breast cancer

8 May 2024

Abstract excerpt

Objective The established link between posttranslational modifications of histone and non-histone lysine (K) residues in cell metabolism, and their role in cancer progression, is well-documented. However, the lactylation expression signature in triple-negative breast cancer (TNBC) remains underexplored. Methods We conducted a comprehensive lactylproteome profiling of eight pairs of TNBC samples and their matched...

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PMID: 38779451
DOI: 10.3389/fendo.2024.1328679

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