KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression.

doi:10.1038/s41418-025-01533-4

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Article

KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression.

Cell death and differentiation - 1 Dec 2025

Zhang Chi, Yu Runfeng, Li Senmao, Yuan Ming, Hu Tuo, Liu Jiaqi, Ke Haoxian, Ye Shubiao, Yun Jihye, Huang Junfeng, Liang Guanzhan, Chen Shaopeng, Wu Xianrui, Lan Ping

Abstract excerpt

Histone lactylation is a novel epigenetic modification derived from lactate, but its role and mechanism in KRAS mutant colorectal cancer (CRC) progression remains to be fully elucidated. In this study, we first showed that mutant KRAS increased H3 lysine 9 lactylation (H3K9la) to promote CRC progression. We found that KRAS-mutant CRC tissues and cell lines exhibited higher lactylation and H3K9la levels compared...

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Topics

Colorectal Neoplasms
Humans
Histones
Proto-Oncogene Proteins p21(ras)
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Mutation

Disease Progression

Cell Line, Tumor

Cell Proliferation

Lysine

Female

Mice, Nude

Male

Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40707783
DOI: 10.1038/s41418-025-01533-4
PMCID: PMC12669710

Genes

KRAS
GRAMD1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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