Article

Lactate Increases Stemness of CD8 <sup>+</sup> T Cells to Augment Anti-Tumor Immunity

2021-10-18

Abstract excerpt

Nutrients and metabolites play important roles in immune functions. Recent studies show lactate instead of glucose can serve as a primary carbon fuel source for most tissues. The role of lactate in tumor immunity is not well understood with immune suppressive functions reported for lactic acid, the conjugate acid form of lactate. In this study, we report lactate increases the stemness of CD8 + T cells and augment...

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Literature Corpus work: 20f63fb0-5b6e-51e3-a735-276054e7a23a
DOI: 10.1101/2021.10.18.464724

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